Connected health system for monitoring adherence | Sagentia Innovation

Verihaler: Connected health system for monitoring adherence

Lack of adherence (or non-compliance) to the drug dosage regimen is a large and growing problem for the healthcare industry, across many indications, patient demographics and even where the disease is potentially life threatening.

Adherence to inhaled drug therapies falls near the bottom of the league, with an average of only 40% to 60% of patients with COPD (Chronic Obstructive Pulmonary Disease) correctly adhering to the prescribed regimen and only 10% of patients with a metered dose inhaler performing all essential steps correctly (Int J Chron Obstruct Pulmon Dis. 2008 September; 3(3): 371–384).

Asthma patients using inhaled drugs exhibit a similar lack of adherence and poor technique (Prim Care Respir J 2011; 20(2): 148-154).

VeriHaler* uses wireless acoustic monitoring to provide valuable feedback to the user, clinician or healthcare provider through promoting correct inhaler usage and rapidly detecting any deterioration in a patient’s condition.

The core sensor technology incorporates a small, inexpensive condenser microphone attached to the device casing. It is non-invasive in the drug flow path and does not affect inhaler performance. It can be retrofitted to an existing inhaler platform and works with both metered dose (pMDI) and dry powder (DPI) inhalers.

A proprietary algorithm removes unwanted background noise from the acoustic signal and extracts key information about the use of the device. For example, parameters such as peak inspiratory flow rate, timing of breath-actuated firing mechanisms and the delivery of the drug formulation itself have all been successfully extracted. It also records time and date of usage.

User feedback and remote connectivity to the carer is critical for the success of this system. An iPhone App communicates with the inhaler via a Bluetooth® Low Energy connection. The iPhone user interface has been designed to ensure that the user is presented with clear, actionable information on the level of their compliance. The App is also capable of logging peak flow data (either from a Bluetooth connected digital peak flow meter or simply via user input). This allows the patient to spot any deterioration in their condition early on. Finally, the logged data are then uploaded to a cloud server via a secure connection. This feature enables a secure web portal, through which the patient and the clinician can review these data during a consultation and can rapidly determine whether or not, for example, any deterioration in the patient’s condition is related to poor compliance or simply inappropriate medication.

The figure below shows many of the challenges that we are addressing in the development of this novel system. In particular, we anticipate the App will be regulated as a Medical Device in accordance with the FDA’s recently released guidelines on Mobile Medical Apps. This means that the system must be carefully designed to ensure that critical data processing steps are not carried out on the smart mobile device processor, but either within the medical device or on a remote server.

Elements of the technology have been used by two pharmaceutical companies in their clinical trials (one pMDI, one DPI).

Image

What’s special about us?

Why do we do it?

Where we add value

Did you know?

What’s special about us?

  1. We put you first. If we work on a patentable piece of technology on behalf of a client, our clients always get the IP
  2. We deliver. We combine strategic thinking and market analysis skills with science and technology consultancy and product development to create plans, deliverables, and results
  3. We challenge. Think of a question you’d ask us about a given direction, market or trend. Is it the right question? Is what you’re asking for really the thing that will achieve your objective?
  4. We’re fast. It’s possible to take a three year plan and execute in 18 months, and to take a 12 month plan and execute in 3
  5. We’re fun to work with. We make the effort to really understand your business and your challenges so we can craft solutions that are specific to your needs

Why do we do it?

  1. Because it matters. We seek to help our clients make a difference to real lives
  2. To raise the bar. By sharing our breadth of expertise and experience across the markets we know we can facilitate and accelerate successful innovative growth and business strategies
  3. For our clients. When we work with our clients they see us as their partners. Their success is vital to us and we are genuinely excited and delighted when they select us to be part of their journey to research and develop
  4. We love it. We’re fascinated by science and technology, the world in which we live and the macro trends and issues which are changing our lives. We want to help shape transformation

Where we add value

  1. If something seems an impossible task, we can deconstruct it with you and come up with a plan
  2. We will take on moonshots
  3. We believe we have one of the widest skills bases anywhere and can take on some of the more unusual or challenging projects. If it’s a weird one, give us a shout
  4. We’ll always tell you if we can’t help, or if we think there’s someone better for the job
  5. If you are responsible for looking at macro trends in your businesses that might pose a threat or create an opportunity and you need to do more digging – we can dig for you. And more than that we’ll make sense of what we find and give you next steps
  6. We enjoy our work. And we think you’d enjoy working with us too

Did you know?

  1. Our top 2 most common project requests are in sustainability and digital transformation
  2. We speak more than 20 languages
  3. We have a dedicated IoT infrastructure, Nuvola, with 4.8m live devices connected to it
  4. Our electron microscope is a Zeiss Evo Scanning Electron Microscope and is used every day
  5. We created hollow sugar, in 2011
  6. We have UKAS accredited food kitchens
  7. We are 13485 accredited and have been for 20 years
  8. We architected and coded cloud infrastructure for a major industrial client
Haven't found what you were looking for?

Our marketsarrow pointing rightarrow pointing right

Our consultants, scientists and engineers redefine what’s possible and help R&D groups across the medical, industrial, consumer and food and beverage sectors achieve commercial return from their opportunities.

Our projectsarrow pointing rightarrow pointing right

We have completed over 10,000 projects for start-ups and global market leaders alike, from understanding the market & technology landscape through to developing and delivering complex products.

Get in touch